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Quantitative morphologic changes in nephron structures and urinary enzyme activity pattern in sodium-maleate-induced renal injury.

W Pfaller·M Joannidis·G Gstraunthaler·P Kotanko
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Abstract

The morphologic changes in sodium-maleate-induced acute renal injury in the rat were quantified by a stereologic analysis. The major changes were confined to an increase in endocytic vacuoles and a decrease in mitochondrial inner membrane surface area. These results were found to be linked to significantly increased urinary activities of the cytosolic of the cytosolic enzymes fructose-1,6-bisphosphatase (FBP) and lactate dehydrogenase, the lysosomal enzyme N-acetyl-beta-glucosaminidase (NAG) and the NAD-dependent mitochondrial isocitrate dehydrogenase (ICDH). The highest increase was found for NAG, followed by FBP and ICDH.

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AnimalsCell MembraneEnzymesGlomerular Filtration RateKidney DiseasesLysosomesMaleMaleatesMitochondriaNephronsRatsRats, Inbred StrainsStereoisomerismJournal ArticleResearch Support, Non-U.S. Gov't

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W Pfaller, M Joannidis, G Gstraunthaler, P Kotanko. Quantitative morphologic changes in nephron structures and urinary enzyme activity pattern in sodium-maleate-induced renal injury.. https://doi.org/10.1159/000173180

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