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DHPR activity decrease in dried blood spots stored at 4 degrees C.

G Lenzi·D Pistone·E Zammarchi·M P Benini·A La Torre·D Matteoni
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Abstract

Dihydropteridine reductase (DHPR) activity has been measured in dried blood spots by the Arai method in 286 subjects divided into 4 groups: 45 newborns aged between 4 and 7 days; 40 subjects with hyperphenylalainaemia; 199 apparently normal subjects, and 2 patients with DHPR deficiency. Furthermore, a study of the persistence of enzymatic activity on the spots stored at 4 degrees C revealed that after 1 year it decreased to one third of the original value, corresponding to the mean value of controls minus 2 SD.

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Amino Acid Metabolism, Inborn ErrorsBlood Specimen CollectionCold TemperatureDesiccationDihydropteridine ReductaseEnzyme StabilityHumansInfant, NewbornNADH, NADPH OxidoreductasesPhenylalaninePhenylketonuriasReference ValuesJournal Article

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BibTeXRIS

G Lenzi, D Pistone, E Zammarchi, M P Benini, A La Torre, D Matteoni. 1989. DHPR activity decrease in dried blood spots stored at 4 degrees C.. https://doi.org/10.1159/000469049

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