Murine complement component 3: genetic variation and linkage to H-2.

F P Da Silva; G F Hoecker; N K Day; K Vienne; P Rubinstein

doi:10.1073/pnas.75.2.963

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Murine complement component 3: genetic variation and linkage to H-2.

F P Da Silva·G F Hoecker·N K Day·K Vienne·P Rubinstein

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Abstract

Two electrophoretic variants of murine complement component 3 (C3) were detected by using high-voltage electrophoresis of fresh mouse serum in agarose gels. Most of the inbred strains tested were homozygous for the S allele (for the slow-migrating variant); only four out of 46 strains had the alternative F allele (fast variant). Pen-bred Swiss-Webster animals belonged to one of three phenotypes--S, F, or SF--and the genes responsible for this variation segregated in a strictly Mendelian manner. In three such crosses, with 5* offspring, C3 segregated with H-2 in 46 instances, corresponding to a recombination frequency of approximately equal to 0.12.

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Animals Complement C3 Electrophoresis Genes Genetic Linkage Genetic Variation Histocompatibility Mice Mice, Inbred Strains Journal Article Research Support, U.S. Gov't, P.H.S.

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F P Da Silva, G F Hoecker, N K Day, K Vienne, P Rubinstein. 1978. Murine complement component 3: genetic variation and linkage to H-2.. https://doi.org/10.1073/pnas.75.2.963

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