The alternative hypothesis: one-sided or two-sided?

K E Peace

doi:10.1016/0895-4356(89)90137-6

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The alternative hypothesis: one-sided or two-sided?

K E Peace

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Abstract

The appropriateness of a one-sided alternative hypothesis rather than the more conservative, boiler-plate, two-sided hypothesis is discussed and examples provided. It is concluded that confirmatory efficacy clinical trials of pharmaceutical compounds should always be viewed within the one-sided alternative hypothesis testing framework.

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K E Peace. 1989. The alternative hypothesis: one-sided or two-sided?. https://doi.org/10.1016/0895-4356(89)90137-6

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