Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences.

F Vartdal; L M Sollid; B Vandvik; G Markussen; E Thorsby

doi:10.1016/0198-8859(89)90074-8

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Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences.

F Vartdal·L M Sollid·B Vandvik·G Markussen·E Thorsby

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Abstract

Of 61 Norwegian multiple sclerosis patients tested, 59, i.e., 97%, were positive for at least one of the HLA specificities DR2, DR4, or DRw6. Typing with sequence-specific oligonucleotide probes revealed that the same 59 patients carried DR2-, DR4-, or DRw6-associated HLA-DQB1 genes which encode shared polymorphic amino acid sequences in the membrane-distal part of their HLA-DQ beta chains. This shared DQ beta polymorphism may explain previously reported DR associations and could thus be the primary HLA association in MS.

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Amino Acid Sequence DNA Probes, HLA Gene Frequency Genes, MHC Class I Genetic Markers HLA-DQ Antigens HLA-DR Antigens Humans Molecular Sequence Data Multiple Sclerosis Polymorphism, Genetic Journal Article Research Support, Non-U.S. Gov't

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F Vartdal, L M Sollid, B Vandvik, G Markussen, E Thorsby. 1989. Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences.. https://doi.org/10.1016/0198-8859(89)90074-8

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