A double-loop model for the replication of eukaryotic DNA.

S Spadari; A Montecucco; G Pedrali-Noy; G Ciarrocchi; F Focher; U Hübscher

doi:10.1016/0921-8734(89)90009-x

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A double-loop model for the replication of eukaryotic DNA.

S Spadari·A Montecucco·G Pedrali-Noy·G Ciarrocchi·F Focher·U Hübscher

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Abstract

Coordinated DNA synthesis of both strands at the replication fork by a fixed 'replisome' may cause dynamic and topological problems. Based upon known properties of DNA helicase, DNA primase and DNA topoisomerases, and on novel properties of DNA polymerases and DNA ligase, we propose a 'double-loop' model for the replication of eukaryotic DNA that could minimize such problems.

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Animals DNA DNA Ligases DNA Polymerase II DNA Polymerase III DNA Replication DNA-Directed DNA Polymerase Models, Genetic Models, Molecular Journal Article Research Support, Non-U.S. Gov't

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S Spadari, A Montecucco, G Pedrali-Noy, G Ciarrocchi, F Focher, U Hübscher. 1989. A double-loop model for the replication of eukaryotic DNA.. https://doi.org/10.1016/0921-8734(89)90009-x

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