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Lithocholate in liver tissue with obstructive jaundice.

J Yanagisawa·M Nagai·Y Hirano·T Fujii·F Nakayama
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Abstract

The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922-929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hepatic dysfunction in obstructive jaundice is minimal, if any.

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CholestasisGas Chromatography-Mass SpectrometryHumansLithocholic AcidLiverJournal Article

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J Yanagisawa, M Nagai, Y Hirano, T Fujii, F Nakayama. 1989. Lithocholate in liver tissue with obstructive jaundice.. https://doi.org/10.1007/bf02774190

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