PubMed · 27462
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T M Chang. 1978. Artificial cells in 1977.. https://pubmed.ncbi.nlm.nih.gov/27462/
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In 36 treated diabetics (15 with insulin, 21 with oral hypoglycaemic agents) without any detectable arterial atheromatous lesion, there was a negative correlation between the filtrability of red cells and blood glucose levels (r = - 0.60) on the one hand and, secondly, glycosylated haemoglobin levels (r = - 0.40). In 17 insulindependents diabetics connected to an artificial pancreas, normalisation of blood glucose was accompanied by a concomitant increase in the filtrability of red cells, and improvement of spontaneous platelet agregation. Good control of diabetes would thus appear to be necessary to reduce the incidence of microangiopathy.
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Reproducible and reliable quantitative glucose determinations in physiological solutions of saline can be obtained by using platinum powder incorporated in a thin plastic layer on a platinum wire as the test microelectrode, while applying analytic and regenerative pulses of alternating voltage of +/- 1 V (sce). The results are the beginning of further investigations leading to continuous determinations of glucose concentration in body fluids.