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Neurotensin-induced polydipsia: a structure-activity study.

M F Hawkins·J D Baker·A A Baumeister
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Abstract

Neurotensin (NT) and equimolar concentrations of NT fragments were microinjected into the lateral cerebral ventricle of water-deprived rats. NT (10 micrograms) increased water intake 146% in the first 15 min following injection. While NT1-11 and NT10-13 had no effect on water intake, NT8-13 increased water intake 101%. The polydipsia produced by NT8-13 was statistically equivalent to that produced by NT. The results are discussed in relation to a proposed model of the NT receptor.

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AnimalsBrainDrinking BehaviorInjections, IntraventricularMaleNeurotensinPeptide FragmentsRatsRats, Inbred StrainsThirstJournal Article

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M F Hawkins, J D Baker, A A Baumeister. 1989-05-15. Neurotensin-induced polydipsia: a structure-activity study.. https://doi.org/10.1016/0006-8993(89)90957-8

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