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PubMed · 2759312

[Experiences with cinnamic acid esters as sunscreening agents].

G Würbach·H Kewitsch
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Abstract

After incorporation in ointment bases and cosmetics usual in trade 2-Ethylhexyl-4-methoxycinnamat being known as skin compatible was investigated for light protection efficacy in determining the sun protection factor (SPF). Despite different penetration power into the stratum corneum we obtained low SPF from all tested oils. In emulsion bases as a rule the SPF corresponded to the concentration of the filter, respectively little lower values were found. Most of the SPF-values did not vary significantly, although the investigated preparations were different in emulsions-type, ingredients and additives. Formulations containing 2-Ethylhexyl-4-methoxycinnamat in bases being of pharmacopoeial quality are recommended as alternative for incompatible sun cosmetics and drugs.

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CinnamatesDose-Response Relationship, RadiationHumansOintment BasesSunscreening AgentsComparative StudyEnglish AbstractJournal Article

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BibTeXRIS

G Würbach, H Kewitsch. 1989. [Experiences with cinnamic acid esters as sunscreening agents].. https://pubmed.ncbi.nlm.nih.gov/2759312/

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Optimization of the solvent-tolerant Pseudomonas putida S12 as host for the production of p-coumarate from glucose.

A Pseudomonas putida S12 strain was constructed that is able to convert glucose to p-coumarate via the central metabolite L: -tyrosine. Efficient production was hampered by product degradation, limited cellular L: -tyrosine availability, and formation of the by-product cinnamate via L: -phenylalanine. The production host was optimized by inactivation of fcs, the gene encoding the first enzyme in the p-coumarate degradation pathway in P. putida, followed by construction of a phenylalanine-auxotrophic mutant. These steps resulted in a P. putida S12 strain that showed dramatically enhanced production characteristics with controlled L: -phenylalanine feeding. During fed-batch cultivation, 10 mM (1.7 g l(-1)) of p-coumarate was produced from glucose with a yield of 3.8 Cmol% and a molar ratio of p-coumarate to cinnamate of 85:1.

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