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A specific chromosome breakpoint associated with mouse plasmacytomas.

J S Shepard·O S Pettengill·D H Wurster-Hill·G D Sorenson
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Abstract

The chromosomes of uncultured cells of the near-diploid mouse plasmacytoma MOPC-31C were studied. The modal number of chromosomes was 44. The tumor lacked two marker chromosomes, reciprocal translocation [rcp t(12; 15)], that in previous studies were found to be common to 3 other uncultured myelomas and 1 cultured mouse myeloma. Through the formation of two markers, rcp t(6; 15), unique to this tumor, however, the tumor shared with other tumors and their specific markers a common breakpoint in chromosome "15 at band D3/E. This breakpoint has been found in all mouse plasmacytomas examined with banding thus far and is considered of possible importance in the development of this tumor.

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AnimalsChromosome AberrationsChromosome DeletionChromosomes, Human, 21-22 and YFemaleHumansLeukemia, MyeloidLeukemia, Plasma CellMiceMice, Inbred BALB CMultiple MyelomaPlasmacytomaSarcoma, ExperimentalTranslocation, GeneticTrisomyX ChromosomeJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J S Shepard, O S Pettengill, D H Wurster-Hill, G D Sorenson. 1978. A specific chromosome breakpoint associated with mouse plasmacytomas.. https://doi.org/10.1093/jnci%2F61.1.255

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