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PubMed · 277259

Nitropyrrole radiosensitizers: structure function relationships.

J A Raleigh·J D Chapman·A P Reuvers·J E Biaglow·R E Durand·A M Rauth
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Abstract

Nitropyrrole derivatives have been tested as hypoxic cell radiosensitizers in vitro and in vivo. Radiosensitizing potential generally increases with nitropyrrole electron affinity. N-hydroxyethyl substitution decreases toxicity relative to N--CH3, N--CH2 CH3 and N--CH2 CH2 CH3 substitution. The most effective nitropyrrole tested in vivo is N-hydroxyethyl-2-cyano-5-nitropyrrole (NP-1).

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AnimalsCell SurvivalIn Vitro TechniquesMiceNeoplasms, ExperimentalOxygen ConsumptionPyrrolesRadiation-Sensitizing AgentsStructure-Activity RelationshipJournal Article

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J A Raleigh, J D Chapman, A P Reuvers, J E Biaglow, R E Durand, A M Rauth. 1978. Nitropyrrole radiosensitizers: structure function relationships.. https://pubmed.ncbi.nlm.nih.gov/277259/

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