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Heparinizable segmented polyurethanes containing poly-amidoamine blocks.

M C Tanzi·M Levi
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Abstract

A poly-ether-urea-urethane was synthesized by copolymerization of 4,4'-diphenylmethanediisocyanate (MDI), propanediamine, and poly-oxytetra-methylene glycol (M.W. 1000). Two other corresponding copolymers were also synthesized by adding amino terminated poly-amidoamine macromonomers, purposely synthesized, so as to insert relatively small amounts (6 and 15 weight %) of two types of poly-amidoamine segments in the final product. Of the three copolymers several physicochemical and mechanical properties have been determined, and their heparin adsorption ability, blood compatibility, and cytotoxicity evaluated.

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AdsorptionAnimalsBiocompatible MaterialsCell DivisionCell LineEthersHeparinIndicators and ReagentsMicroscopy, Electron, ScanningMolecular StructurePolymersPolyurethanesSpectrophotometry, InfraredTensile StrengthUreaJournal ArticleResearch Support, Non-U.S. Gov't

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M C Tanzi, M Levi. 1989. Heparinizable segmented polyurethanes containing poly-amidoamine blocks.. https://doi.org/10.1002/jbm.820230805

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