PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 27851

Weak acids, weak bases and intracellular pH.

A Roos
View original source ↗Export metadata ↓

Abstract

Against the background of classical observations made 50 years ago, a brief review is offered of some of the work performed in the author's laboratory on the behavior of weak acids and bases towards living animal cells. The significance of membrane permeability of the charged partner of these electrolytes is pointed out, and the existence of an active process of H+ extrusion (or its equivalent) in response to acid loading is demonstrated. The effect of intracellular inhomogeneity on weak acid and base transmembrane distribution is examined. The significance of these variables for weak acid- or base-derived intracellular pH is discussed.

Explore related subjects

Acid-Base EquilibriumAnimalsBiological Transport, ActiveCell Membrane PermeabilityChemical PhenomenaChemistry, PhysicalHydrogen-Ion ConcentrationIntracellular FluidJournal ArticleResearch Support, U.S. Gov't, P.H.S.

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Roos. 1978. Weak acids, weak bases and intracellular pH.. https://doi.org/10.1016/0034-5687(78)90080-4

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1979

Suppression of uterine activity with salbutamol before caesarean section.

In 32 patients undergoing emergency intrapartum caesarean section labour was suppressed with 250 micrograms salbutamol. The biochemical status of the neonates was compared with that of 15 controls. The initial results did not demonstrate a major difference between the two groups, but when only proven cases of fetal distress (H less than 7,25) in the two groups were compared, a significant improvement in the PO, pH and base deficit values in the umbilical vein as well as in the PO2 and pH values in the umbilical artery was noted in the group which had been given salbutamol. No major maternal side-effects were noted and this, together with the simplicity of the regimen, makes it a valuable temporizing measure in such cases.

Acid-Base Equilibrium↗
PubMed1979

Blood flow to fetal organs as a function of arterial oxygen content.

In a sheep preparation the blood flow to fetal organs was studied 3 to 10 days after surgery by means of the microsphere technique over a range of fetal arterial O2 content from 6 to 1 mM. Blood flows to neural tissues (cerebrum, cerebellum, brain stem), heart, and the adrenals increased in inverse relation to arterial O2 content. As a result the arterial supply of O2 to these organs tended to remain constant over the O2 range studied. Blood flow to the fetal lungs decreased progressively with hypoxia. The blood flow to kidneys, digestive tract, pancreas, and carcass had a tendency to remain constant or increase gradually in the transition from high to moderately low levels of arterial O2 content and then to decrease abruptly in more severe hypoxia. Umbilical blood flow did not change systematically in relation to arterial O2 content.

Acid-Base Equilibrium↗