Solubilizing the T-cell receptor--problems in solution.

A Traunecker; B Dolder; F Oliveri; K Karjalainen

doi:10.1016/0167-5699(89)90062-5

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Solubilizing the T-cell receptor--problems in solution.

A Traunecker·B Dolder·F Oliveri·K Karjalainen

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Abstract

Recombinant DNA technology has been central in answering some of the most important questions in immunology and has recently helped to define the complex of membrane associated proteins on T-cell surfaces responsible for antigen recognition. Here André Traunecker and colleagues describe attempts to facilitate the analysis of this complex using genetic engineering to produce solubilized T-cell receptor and associated molecules.

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Animals Antigens, Differentiation, T-Lymphocyte Cloning, Molecular Genes, Synthetic Histocompatibility Antigens Class II Humans Membrane Proteins Mice Protein Conformation Receptors, Antigen, T-Cell Recombinant Fusion Proteins Recombinant Proteins Solubility T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't

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A Traunecker, B Dolder, F Oliveri, K Karjalainen. 1989. Solubilizing the T-cell receptor--problems in solution.. https://doi.org/10.1016/0167-5699(89)90062-5

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