PubMed · 2788336
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D A Fredriks. Comment: TMP/SMX--warfarin interaction.. https://doi.org/10.1177/1060028089023007-827
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Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.