PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 27946

[Actual knowledge on beta blocking agents in psychiatry (author's transl)].

H Scharbach
View original source ↗Export metadata ↓

Abstract

A new group of substances blocking central beta receptors, ie beta blocking agents among which oxprenol and pindolol, have been used in psychiatry, mainly in anxious or depressive-anxious patients. The anxiolytic effect, particularly on somatic anxiety, is interesting, and is present in double blind studies with benzodiazepines, where it is superior to these classical agents. The author has observed this therapeutic activity in series of one hundred patients and also a dynamising effect in some of these patients. Without having observed by himself and possibly because of the low doses experimented, the author states that these drugs have an antipsychotic activity.

Explore related subjects

Adrenergic beta-AntagonistsAnimalsAttentionBrainCatsChemical PhenomenaChemistryDrug ToleranceEmotionsHumansMental DisordersMental ProcessesNeural ConductionPeripheral NervesSleepEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H Scharbach. [Actual knowledge on beta blocking agents in psychiatry (author's transl)].. https://pubmed.ncbi.nlm.nih.gov/27946/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1979

[The influence of a beta-adrenolytic premedication on cardiovascular parameters and plasma free fatty acids during esophago-gastro-duodenoscopy (author's transl)].

Three groups of patients with different premedications were examined for changes of blood pressure, heart rate, ECG and plasma free fatty acid levels during esophago-gastro-duodenoscopy: Group A was premedicated with Bunitrolol, group B was premedicated with Hyoscin-N-butyl-bromide and diazepam, group C was endoscopied without premedication. The pulse rate rose significantly less in group A than in groups A and C; the same phenomenon was observed with regard to the systolic blood pressure. Premature beats occurred in all 3 groups: 32 per cent of the patients in group A, 43 per cent in group B and 60 per cent in group C had at least occasional premature beats; an accumulation of premature beats however occurred significantly less frequently in group A than in groups B or C. A drop of the ST-part of the ECG occurred with about the same frequency in each group. An increase of the plasma free fatty acids, which was noted in groups B and C, could be observed in Group A. A pre-endoscopic medication of beta blocking agents could be a useful measure in patients with labile arterial hypertension, vegatative dysregulation and a hyperkinetic heart syndrome.

Adrenergic beta-Antagonists↗
PubMed1979

Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs.

Two new beta-adrenoceptor blocking drugs with acute antihypertensive and positive inotropic effects are described: Compound A (2-[4-(3-tert.butylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole) and MK-761 (2-(3-tert.butylamine-2-hydroxypropoxy)-3-cyanopyridine hydrochloride). In SH rats both compounds, given orally, lowered arterial pressure and were more potent than hydralazine. The antihypertensive effect of compound A but not of MK-761 was antagonized by timolol. Both compounds had positive inotropic activity on cat heart papillary muscles; these effects were antagonized by timolol. The pretreatment of animals with reserpine greatly reduced the positive inotropic effect of MK-761 but not of compound A. The acute antihypertensive and positive inotropic effects of compound A are like to be at least partially due to stimulation of beta-adrenoceptors, e.g. intrinsic sympathomimetic activity. The effects of MK-761 on the same parameters appear to be mediated by different mechanisms.

Adrenergic beta-Antagonists↗