[Studies with temocillin].

Abstract

This is a report about microbiological investigations with a new Penicillin-derivate. Temocillin is the first beta-lactamase stable Penicillin with an excellent bactericidal effect against almost all clinically important gram-negative aerobic germs. The antibacterial activity of Temocillin was determined against 355 multiresistent Enterobacteriaceae-strains. We ascertained minimal bacteriostatic and the minimal bactericidal concentration with help of macrodilution-test. The ratio of resistant strains amounted to 0.8%. In vitro investigations with the combination Temocillin and Gentamicin (checker-board-technique) showed 91% indifference and 9% addition, respectively, in 35 Enterobacteriaceae-strains, investigated. Resistances against Temocillin and Ampicillin were cultured through subinhibitory concentrations to predict parallel resistances possible.