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Human alpha-L-fucosidase: complete coding sequence from cDNA clones.

T Occhiodoro·K R Beckmann·C P Morris·J J Hopwood
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Abstract

The human lysosomal storage disorder fucosidosis results from the deficiency of alpha-L-fucosidase, a lysosomal enzyme essential for the catabolism of oligosaccharides containing alpha-L-fucosides. cDNA clones coding for human alpha-L-fucosidase have been isolated from lambda gt10 and lambda gt11 cDNA libraries derived from human liver, placenta and colon. Compilation of cDNA sequences results in a nucleotide sequence of 2053 base pairs encoding alpha-L-fucosidase. The sequence contains an open reading frame of 461 amino acids beginning with the first in-frame methionine and includes 439 amino acids which comprise the mature protein in addition to a hydrophobic signal peptide sequence of 22 amino acids.

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Amino Acid SequenceBase SequenceDNADNA ProbesGenomic LibraryHumansMolecular Sequence DataRestriction Mappingalpha-L-FucosidaseJournal ArticleResearch Support, Non-U.S. Gov't

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T Occhiodoro, K R Beckmann, C P Morris, J J Hopwood. 1989-10-16. Human alpha-L-fucosidase: complete coding sequence from cDNA clones.. https://doi.org/10.1016/0006-291x(89)91739-7

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