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PubMed · 2803801

[Choreo-ballistic status treated by GABA].

M Hashimoto·A Yokota·S Matsuoka·F Shima
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Abstract

A successful GABA replacement therapy for choreo-ballistic status in a 9-year-old girl, who had been previously treated medically or surgically without beneficial results, was reported. Involuntary movements completely ceased after intravenous administration of GABA (the maximal doses: 533 mg/kg/day) of 3 weeks' duration. Chorea and ballism are assumed to be caused by hypofunction of the GABA-neurons in the basal ganglia. Administration of GABA has been considered to be ineffective for these involuntary movements, since GABA has been believed not to cross the blood-brain barrier. The present case suggests that a large amount of intravenous administration of GABA gives a chance to treat involuntary movements caused by deficiency of GABA-neurons, although the essential mechanism of intracerebral penetration of GABA remains uncertain.

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ChildChoreaFemaleHumansMovement Disordersgamma-Aminobutyric AcidCase ReportsEnglish AbstractJournal Article

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BibTeXRIS

M Hashimoto, A Yokota, S Matsuoka, F Shima. 1989. [Choreo-ballistic status treated by GABA].. https://pubmed.ncbi.nlm.nih.gov/2803801/

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