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PubMed · 2804470

High chlorpromazine doses and liver function.

O Castro-e-Silva Júnior·R Ceneviva·J E Roselino
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Abstract

The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups: control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/kg body weight followed by daily doses of 10 mg/kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control (activated/basal ratio) were detected between the two groups.

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Alanine TransaminaseAlkaline PhosphataseAnimalsBilirubinChlorpromazineLiverMaleMitochondria, LiverRatsRats, Inbred StrainsTissue PreservationJournal ArticleResearch Support, Non-U.S. Gov't

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O Castro-e-Silva Júnior, R Ceneviva, J E Roselino. 1989. High chlorpromazine doses and liver function.. https://pubmed.ncbi.nlm.nih.gov/2804470/

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