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Effect of levodopa on the human pattern electroretinogram and pattern visual evoked potentials.

I Gottlob·H Weghaupt·C Vass·E Auff
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Abstract

Pattern electroretinograms (P-ERGs) and pattern visual evoked potentials (P-VEPs) were recorded at three luminance levels and five different check sizes in a group of 16 control subjects before and after the oral administration of levodopa. At the lower luminance levels, significant decrease in P-ERG and P-VEP latencies were found. For P-VEPs the latency changes occurred only at small check sizes. No changes were observed in control experiments without levodopa administration. Our results show that levodopa-induced changes even occur at the retinal level and support a dopaminergic involvement in light and dark adaptation. Our observations are in agreement with a VEP delay found in Parkinson's disease and with a VEP latency increase in rats after dopamine depletion.

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Administration, OralAdultElectroretinographyEvoked Potentials, VisualFemaleForm PerceptionHumansLevodopaMalePattern Recognition, VisualRandom AllocationTime FactorsVisual AcuityClinical TrialJournal ArticleRandomized Controlled Trial

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I Gottlob, H Weghaupt, C Vass, E Auff. 1989. Effect of levodopa on the human pattern electroretinogram and pattern visual evoked potentials.. https://doi.org/10.1007/bf02172892

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