[Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine].

A K Nersesian; V N Zil'fian; V A Kumkumadzhian

PubMed · 2815329

[Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine].

A K Nersesian·V N Zil'fian·V A Kumkumadzhian

Abstract

Immunization of Wistar rats with tularemic vaccine has been studied for its influence on the cytogenetic effect of adryblastine and pharmorubicyn. It is shown that the number of aberrant metaphases considerably decreases in the myelocaryocytes of vaccinated rats. Antimutagenic effect is induced by the influence of tularemic vaccine on the metabolic activation processes of antibiotics and, possibly, by an increase of the activity of antioxidative enzymes in the rat organism.

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Animals Bacterial Vaccines Chromosome Aberrations Doxorubicin Epirubicin Francisella tularensis Male Rats Rats, Inbred Strains Journal Article

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A K Nersesian, V N Zil'fian, V A Kumkumadzhian. [Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine].. https://pubmed.ncbi.nlm.nih.gov/2815329/

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