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PubMed · 2824238

Receptor-phosphoinositidase C coupling. Multiple G-proteins?

W W Lo·J Hughes
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Abstract

Recent evidence has suggested that receptor-mediated phosphoinositide turnover, like that of the adenylate cyclase cAMP pathway, is regulated by guanine nucleotides. It is likely that one or more guanine nucleotide-binding proteins (G-proteins) couple calcium-mobilizing receptors to the activation of phosphoinositidase C. Recent studies utilizing various bacterial toxins have strongly suggested the presence of multiple G-proteins in the regulation of receptor-phosphoinositidase C coupling in a variety of cell types.

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Adenylyl CyclasesAnimalsBacterial ToxinsEnzyme ActivationGTP-Binding ProteinsHumansPhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphoric Diester HydrolasesProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Receptors, Cell SurfaceJournal ArticleResearch Support, Non-U.S. Gov'tReview

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W W Lo, J Hughes. 1987-11-16. Receptor-phosphoinositidase C coupling. Multiple G-proteins?. https://doi.org/10.1016/0014-5793(87)80410-6

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