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MPDP+ causes a non-reversible decrease in neostriatal synaptic transmission in mouse brain slice.

J A Wilson·J S Wilson·F F Weight
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Abstract

MPTP causes a Parkinson's disease-like syndrome in man and certain other animals. The toxic effect occurs if monoamine oxidase B is available, indicating that an MPTP metabolite may cause the toxic effect. We tested the effect of MPDP+, the first product of MPTP oxidation, and found that it, like MPTP, caused a non-reversible decrease in synaptic transmission in the mouse brain slice preparation. As the second oxidation product, MPP+ had been shown not to cause a similar, non-reversible decrease in synaptic transmission, MPDP+ is a better candidate for the role of toxic substance.

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AnimalsCorpus StriatumIn Vitro TechniquesMicePargylinePyridinium CompoundsSynapsesSynaptic TransmissionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J A Wilson, J S Wilson, F F Weight. 1987-11-10. MPDP+ causes a non-reversible decrease in neostriatal synaptic transmission in mouse brain slice.. https://doi.org/10.1016/0006-8993(87)90524-5

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