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A human tRNA(iMet) gene produces multiple transcripts.

C L Vnencak-Jones·S Z Wahab·Z E Zehner·W M Holmes
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Abstract

A third nonallelic locus of the human methionyl-tRNA multigene family (tRNA(iMet-3) was isolated. This gene, unlike two other tRNA(iMet) loci, lacks a remarkable run of T and C residues which functions as a termination of transcription signal. Instead, three tandem termination signals, each containing no more than four thymidylate residues, function as relatively inefficient termination signals. As a result, polymerase readthrough generates at least three transcripts in vitro. The efficiency of apparent termination varies significantly at these sites. All resulting transcripts appear to be processed in vitro.

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Base SequenceDNA Restriction EnzymesGenesHumansMolecular Sequence DataRNA Processing, Post-TranscriptionalRNA, Transfer, Amino Acid-SpecificRNA, Transfer, MetTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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C L Vnencak-Jones, S Z Wahab, Z E Zehner, W M Holmes. 1987. A human tRNA(iMet) gene produces multiple transcripts.. https://doi.org/10.1128/mcb.7.11.4134-4138.1987

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