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PubMed · 2829005

Presynaptic alpha 2 adrenoreceptor function in dependent rats before and after morphine withdrawal.

H C Moises·C B Smith·R N Spengler·P J Hollingsworth
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Abstract

Changes in the number of alpha 2 adrenoreceptors in the hippocampus, as measured by the specific binding of 3H-clonidine, were compared to changes in presynaptic alpha 2 adrenoreceptor function in electrically stimulated hippocampal slices. In dependent rats the specific binding of 3H-clonidine was reduced significantly. At 32 h after withdrawal binding began to return toward normal values, and at 72 h after withdrawal was significantly greater than that seen in saline-treated rats. In hippocampal slice experiments sensitivity to clonidine was significantly decreased in morphine-dependent animals and returned toward normal values after withdrawal. At 72 h after withdrawal, the sensitivity to clonidine of the presynaptic alpha 2 adrenoreceptor remained depressed although receptor density as measured in the binding studies was increased. This study suggests that the changes in the function of presynaptic alpha 2 adrenoreceptors might be important in the development of dependence upon morphine.

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AnimalsClonidineHippocampusIn Vitro TechniquesMaleMorphineMorphine DependenceNorepinephrineRatsRats, Inbred StrainsReceptors, Adrenergic, betaSubstance Withdrawal SyndromeJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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H C Moises, C B Smith, R N Spengler, P J Hollingsworth. 1986. Presynaptic alpha 2 adrenoreceptor function in dependent rats before and after morphine withdrawal.. https://pubmed.ncbi.nlm.nih.gov/2829005/

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