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Complement-mediated cytolytic activity associated with cytomegalovirus complement-fixing IgM antibody.

J C Booth·H S Mohammed
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Abstract

Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cells, suggesting that the CF component of CMV IgM reacts predominantly with antigens on the surface of the infected cells. This also accounts for its complement-mediated cytolytic activity. Neither CMV-specific non-complement-fixing IgM nor CMV-specific IgG demonstrates cytolytic activity.

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Antibodies, ViralAntibody-Dependent Cell CytotoxicityAntigens, ViralComplement System ProteinsCytomegalovirusCytomegalovirus InfectionsHumansImmunoglobulin MIn Vitro TechniquesJournal ArticleResearch Support, Non-U.S. Gov't

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J C Booth, H S Mohammed. 1988. Complement-mediated cytolytic activity associated with cytomegalovirus complement-fixing IgM antibody.. https://doi.org/10.1002/jmv.1890240312

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