[Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].

O F Goloshchapov; Ia M Koen; T S Shuliakovskaia; L P Kaiushin

PubMed · 2844297

[Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].

O F Goloshchapov·Ia M Koen·T S Shuliakovskaia·L P Kaiushin

Abstract

Diethylnitrosamine (DENA) intoxication of rats was accompanied by a reduction of cytochrome P-450 content in the liver, which correlated well with inactivation of cytochrome P-450 during metabolism of DENA in the liver microsomes.

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Animals Biotransformation Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Diethylnitrosamine Electron Spin Resonance Spectroscopy In Vitro Techniques Liver Male Microsomes, Liver Rats Rats, Inbred Strains English Abstract Journal Article

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O F Goloshchapov, Ia M Koen, T S Shuliakovskaia, L P Kaiushin. [Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].. https://pubmed.ncbi.nlm.nih.gov/2844297/

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