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PubMed · 2847262

A structure-activity relationship study on papaverine analogs.

S P Gupta·C Garg·J K Gupta
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Abstract

The structure-activity relationship of papaverine analogs, the inhibitors of adenosine cyclic 3', 5'-monophosphate (c-AMP) phosphodiesterase, is discussed. The enzyme inhibition activity of these compounds are found to be dominantly controlled by hydrophobicity and steric factors. A significant quantitative correlation has been obtained between the inhibition activity and the van der Waals volume.

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3',5'-Cyclic-AMP PhosphodiesterasesPapaverineStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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S P Gupta, C Garg, J K Gupta. 1988. A structure-activity relationship study on papaverine analogs.. https://pubmed.ncbi.nlm.nih.gov/2847262/

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