Catechol estrogen formation in mouse uterus.

C Bunyagidj; J A McLachlan

doi:10.1016/0022-4731(88)90288-9

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Catechol estrogen formation in mouse uterus.

C Bunyagidj·J A McLachlan

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Abstract

Estrogen 2/4-hydroxylase (ESH) and catechol-O-methyltransferase (COMT) activities in mouse liver and uterus were studied. While 2-hydroxyestradiol (2-OHE2) was the predominant product in the liver, equal amounts of 2- and 4-hydroxyestradiol were produced in the uterus. Two-hydroxyestradiol was the preferred substrate for COMT in both tissues, but the level of this enzyme activity was much less in the mouse uterus (17-fold less). Thus, preferential production of 4-hydroxyestradiol (4-OHE2) in the presence of relatively less deactivation provides a mechanism for the local formation of a more chemically active form of estrogen by uterine tissue.

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Animals Aryl Hydrocarbon Hydroxylases Catechol O-Methyltransferase Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1 Estradiol Estrogens, Catechol Female Mice Steroid Hydroxylases Time Factors Uterus Journal Article

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C Bunyagidj, J A McLachlan. 1988. Catechol estrogen formation in mouse uterus.. https://doi.org/10.1016/0022-4731(88)90288-9

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