In vivo EDRF activity influences platelet function.

J C Hogan; M J Lewis; A H Henderson

doi:10.1111/j.1476-5381.1988.tb11616.x

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PubMed · 2850053

In vivo EDRF activity influences platelet function.

J C Hogan·M J Lewis·A H Henderson

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Abstract

The administration of carbachol to rabbits to stimulate the release of endothelium derived relaxing factor (EDRF) results in inhibition of platelet aggregation and elevation of platelet cyclic GMP content. These effects are reversed by simultaneous administration of the EDRF inhibitors methylene blue or haemoglobin. The data provide the first direct biochemical evidence of in vivo EDRF activity.

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Animals Biological Factors Cyclic GMP In Vitro Techniques Nitric Oxide Nitroprusside Platelet Aggregation Rabbits Journal Article

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J C Hogan, M J Lewis, A H Henderson. 1988. In vivo EDRF activity influences platelet function.. https://doi.org/10.1111/j.1476-5381.1988.tb11616.x

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