Beta-adrenergic blockade. An update.

W H Frishman; M Teicher

doi:10.1159/000173885

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PubMed · 2866839

Beta-adrenergic blockade. An update.

W H Frishman·M Teicher

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Abstract

beta-Adrenergic blockade represents a major pharmacologic advance. These drugs bind to membrane adrenergic receptors interfering with the effects of endogenous catecholamines. Eight beta-blockers are available in the United States, and others are being studied. The drugs have varying pharmacodynamic properties that may modify certain side effects: beta 1-selectivity, partial agonism, alpha-adrenergic blocking activity, membrane stabilization, and varying pharmacokinetic characteristics. The drugs have been shown to be relatively safe and useful for a wide variety of cardiovascular and noncardiovascular disease states, and their wide spectrum of therapeutic activity illustrates the importance of the sympathetic nervous system in the pathophysiology of medical illness.

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Action Potentials Adrenergic beta-Antagonists Angina Pectoris Anti-Arrhythmia Agents Arrhythmias, Cardiac Blood Pressure Cardiovascular Diseases Dose-Response Relationship, Drug Heart Conduction System Heart Rate Humans Hypertension Metabolic Clearance Rate Myocardial Contraction Receptors, Adrenergic, alpha Structure-Activity Relationship Journal Article Review

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W H Frishman, M Teicher. 1985. Beta-adrenergic blockade. An update.. https://doi.org/10.1159/000173885

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