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PubMed · 2868767

Chronic schizophrenia.

R Morgan
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Abstract

When I was an SHO at the old Observation Ward at the North Middlesex Hospital in 1954, my immediate boss walked in one day and handed me a piece of paper on which was typed "Largactil 50 mg tds" and said "Try that on the next schizophrenic we get in". What follows is what I have learnt since then.

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Antipsychotic AgentsChronic DiseaseDrug ResistanceHumansSchizophreniaJournal Article

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R Morgan. 1985. Chronic schizophrenia.. https://pubmed.ncbi.nlm.nih.gov/2868767/

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Differential pharmacology of atypical antipsychotics: clinical implications.

PURPOSE: Pharmacology of atypical antipsychotics and the clinical implications are reviewed. SUMMARY: Psychiatric disorders, such as schizophrenia and bipolar disorder, are often associated with poor outcomes. Atypical antipsychotics have become the standard of care for these disorders, and multiple agents have demonstrated efficacy for both acute and maintenance therapy. As a result of their differential pharmacologic properties, atypical antipsychotics have diverse clinical profiles, resulting in different liabilities for specific adverse events. These effects can, in turn, have an adverse impact on patient functionality, adherence to therapy, and overall health. CONCLUSION: Atypical antipsychotics have distinct pharmacological profiles which result in clinically meaningful differences in adverse effects. Clinicians should have a wide choice of agents available with which to optimize outcomes in the majority of patients with psychiatric disorders.

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