Central and peripheral changes in catecholamine-synthesizing enzyme activities after systemic administration of the neurotoxin DSP-4.

R Féty; V Misère; L Lambàs-Señas; B Renaud

doi:10.1016/0014-2999(86)90145-7

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Central and peripheral changes in catecholamine-synthesizing enzyme activities after systemic administration of the neurotoxin DSP-4.

R Féty·V Misère·L Lambàs-Señas·B Renaud

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Abstract

In brain regions containing noradrenergic (NA) cell bodies or terminals, DSP-4 induces changes in the activity of catecholamine-synthesizing enzymes which suggest that central NA neurons are lesioned by this neurotoxin. In contrast, the lack of change in the same enzymatic activities in an area containing mostly adrenergic (A) neurons (C2 region), favors the hypothesis of a resistance of the A neurons to DSP-4. Furthermore, the enzymatic changes observed in peripheral organs suggest a peripheral activation of the NA cell bodies in response to lesioning of the sympathetic terminals by DSP-4.

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Adrenal Medulla Amines Animals Benzylamines Brain Catecholamines Dopamine beta-Hydroxylase Epinephrine Ganglia, Spinal Locus Coeruleus Male Norepinephrine Phenylethanolamine N-Methyltransferase Rats Rats, Inbred Strains Spinal Cord Tyrosine 3-Monooxygenase Journal Article Research Support, Non-U.S. Gov't

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R Féty, V Misère, L Lambàs-Señas, B Renaud. 1986-05-13. Central and peripheral changes in catecholamine-synthesizing enzyme activities after systemic administration of the neurotoxin DSP-4.. https://doi.org/10.1016/0014-2999(86)90145-7

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