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PubMed · 2875666

Neuroleptic-induced tics in two hyperactive children.

C T Gualtieri·D R Patterson
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Abstract

Two hyperactive boys who had developed motor and phonic tics during stimulant treatment reacted similarly to low doses of haloperidol and thioridazine. Neuroleptic-induced tics may be a consequence of presynaptic dopamine blockade.

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Antipsychotic AgentsAttention Deficit Disorder with HyperactivityChildDextroamphetamineHaloperidolHumansMaleMethylphenidateReceptors, DopamineThioridazineTic DisordersCase ReportsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

C T Gualtieri, D R Patterson. 1986. Neuroleptic-induced tics in two hyperactive children.. https://doi.org/10.1176/ajp.143.9.1176

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PURPOSE: Pharmacology of atypical antipsychotics and the clinical implications are reviewed. SUMMARY: Psychiatric disorders, such as schizophrenia and bipolar disorder, are often associated with poor outcomes. Atypical antipsychotics have become the standard of care for these disorders, and multiple agents have demonstrated efficacy for both acute and maintenance therapy. As a result of their differential pharmacologic properties, atypical antipsychotics have diverse clinical profiles, resulting in different liabilities for specific adverse events. These effects can, in turn, have an adverse impact on patient functionality, adherence to therapy, and overall health. CONCLUSION: Atypical antipsychotics have distinct pharmacological profiles which result in clinically meaningful differences in adverse effects. Clinicians should have a wide choice of agents available with which to optimize outcomes in the majority of patients with psychiatric disorders.

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