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PubMed · 2876282

A human tumour model.

A P Forrest·P A Levack·U Chetty·R A Hawkins·W R Miller·J F Smyth·T J Anderson
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Abstract

An approach to the management of patients with large (greater than 4 cm) operable breast cancers is described. The conventional sequence of mastectomy followed by systemic therapy is reversed, allowing accurate measurements of response to individual forms of endocrine therapy or chemotherapy. Such a method not only permits individual selection of appropriate systemic therapy, but also allows clinical response to be related to histological and biochemical tumour parameters. A response was observed in eleven of twenty-three patients to endocrine treatment and in twelve of thirteen to combination chemotherapy. In five of the latter the response was histologically complete.

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Antineoplastic Combined Chemotherapy ProtocolsAxillaBiopsy, NeedleBreast NeoplasmsCombined Modality TherapyFemaleHumansLymph Node ExcisionMammographyMastectomyModels, BiologicalReceptors, EstrogenJournal Article

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A P Forrest, P A Levack, U Chetty, R A Hawkins, W R Miller, J F Smyth, T J Anderson. 1986-10-11. A human tumour model.. https://doi.org/10.1016/s0140-6736(86)92872-2

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