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PubMed · 2876407

[HLA and multiple sclerosis].

A Govaerts
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Abstract

Etiology of and pathogenetic mechanisms in multiple sclerosis are still badly known; therapy is thus uncertain and poorly active. Many recent studies have nevertheless shown a weak but clear association with HLA-DR2, as the possible role of a HTLV-related virus. Infection of genetically sensitive (DR2 positive) children would induce an auto-immune disease with a cellular and humoral reactivity against myelin antigens. A rather active and certainly harmless treatment consists in administration of immunoglobulins.

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Deltaretrovirus InfectionsDisease SusceptibilityGenotypeHLA AntigensHLA-DR AntigensHumansMultiple SclerosisPhenotypeRiskEnglish AbstractJournal Article

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A Govaerts. 1986. [HLA and multiple sclerosis].. https://pubmed.ncbi.nlm.nih.gov/2876407/

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Characterization of mannose-binding lectin gene polymorphism among human T-cell lymphotropic virus 1 and 2-infected asymptomatic subjects.

The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and the susceptibility to human T-cell lymphotropic virus (HTLV) infection in a group of 83 HTLV-infected asymptomatic subjects (62 HTLV-1 and 21 HTLV-2) and 99 healthy controls. Detection of MBL*A, MBL*B, and MBL*C was performed by amplifying a fragment of 349 bp (exon 1) and submitting the product to restriction fragment length polymorphism analysis with BanI and MboII endonucleases. Allele MBL*D was investigated by sequence-specific primer-polymerase chain reaction. The frequency of MBL*A, MBL*B, and MBL*D was 63%, 22%, and 15% among seropositive subjects and 70%, 14%, and 16% among healthy controls, respectively. Genotype differences were statistically significant (chi2 = 11.57; p = 0.04); the presence of genotype BB was 9.6% among HTLV-infected patients compared with 1% among controls (chi2 = 7.151; p = 0.019). A significant difference of the genotype frequencies between HTLV-1 and HTLV-2 infections was observed, but this result could be attributed to the number of investigated HTLV-1-infected subjects. The odds ratio to the presence of BB genotype was 10.453 (1.279 < or = IC95% < or = 85.40; p = 0.019). Results reveal a strong association between MBL polymorphism and HTLV infection. Presence of genotype BB may be associated with the susceptibility to HTLV, but further studies, with a larger number of individuals, will be necessary. MBL polymorphism could possibly have an impact on diseases associated with HTLV infection.

Deltaretrovirus Infections↗