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PubMed · 2883777

[Do vasodilators help in chronic heart failure?].

J Slany
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Abstract

The value of vasodilator drugs in the treatment of patients with chronic congestive heart failure is reviewed on the basis of the randomized double-blind, placebo-controlled trials so far published. Apparently, venous, or combined venous and arteriolar dilation in addition to cardiac glycosides and diuretics may produce long-term improvement in advanced stages of heart failure. Vasodilators with isolated afterload reducing properties seem to be of limited value. Long-term improvement with nitrates and alpha-receptor blocking agents is often modest, probably due to development of tolerance. The most striking results were observed with converting enzyme inhibitors: they evoke virtually no tolerance, improve haemodynamics at rest and during exercise, relieve symptoms of heart failure and are even suggested to reduce mortality.

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Adrenergic alpha-AntagonistsAngiotensin-Converting Enzyme InhibitorsCaptoprilEnalaprilFollow-Up StudiesHeart FailureHemodynamicsHumansVasodilator AgentsClinical TrialComparative StudyEnglish AbstractJournal ArticleRandomized Controlled Trial

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J Slany. 1987-03-06. [Do vasodilators help in chronic heart failure?].. https://pubmed.ncbi.nlm.nih.gov/2883777/

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