Selective T cell defects induced by dopamine administration in mice.

E Kouassi; W Boukhris; J Descotes; P Zukervar; Y S Li; J P Revillard

doi:10.3109/08923978709035227

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Selective T cell defects induced by dopamine administration in mice.

E Kouassi·W Boukhris·J Descotes·P Zukervar·Y S Li·J P Revillard

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Abstract

Dopamine administration in BALB/c mice depressed the overall delayed-type hypersensitivity reaction to sheep red blood cells, the mixed-lymphocyte culture responses, the generation of cytotoxic T cells, and the number of spleen T cell populations. Conversely, dopamine enhanced concanavalin A stimulation of spleen cells, and had no effect on stimulation by PHA, on total spleen and thymus cell number, and on distribution of thymus Ly-t1+ or Ly-t2+ cell subsets. These results indicate that dopamine produces selective T cell defects probably mediated by a direct peripheral action of the drug on subsets of T lymphocytes.

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Animals Dopamine Female Hypersensitivity, Delayed Isoantigens Lymphocyte Activation Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Mitogens Spleen T-Lymphocytes T-Lymphocytes, Cytotoxic Thymus Gland Journal Article Research Support, Non-U.S. Gov't

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E Kouassi, W Boukhris, J Descotes, P Zukervar, Y S Li, J P Revillard. 1987. Selective T cell defects induced by dopamine administration in mice.. https://doi.org/10.3109/08923978709035227

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