Epithelial dysfunction and airway hyperreactivity in asthma.

R G Goldie; L B Fernandes; P J Rigby; J W Paterson

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PubMed · 2898153

Epithelial dysfunction and airway hyperreactivity in asthma.

R G Goldie·L B Fernandes·P J Rigby·J W Paterson

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Abstract

It is clear that the central airway epithelium plays an important role in restricting access of inhaled solutes to sub-epithelial airway wall structures. Non-specific airway hyperreactivity to spasmogens in asthma may result partly as a consequence of the compromise of the epithelium as a barrier to solute diffusion. However, impaired epithelial production and release of smooth muscle relaxant factor(s) may also contribute to airway hyperresponsiveness. Virally precipitated asthma also involves inflammation-induced epithelial damage. Beta-adrenoceptor hypofunction induced by respiratory viruses may also contribute to bronchial obstruction.

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Adrenergic beta-Antagonists Animals Asthma Biological Factors Bronchi Bronchial Spasm Epithelium Humans Muscle Proteins Muscle, Smooth Nitric Oxide Prostaglandins Respiratory Tract Infections Virus Diseases Journal Article Review

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R G Goldie, L B Fernandes, P J Rigby, J W Paterson. 1988. Epithelial dysfunction and airway hyperreactivity in asthma.. https://pubmed.ncbi.nlm.nih.gov/2898153/

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