Histamine H2-receptor antagonists.

R Pounder

doi:10.1016/s0950-3528(88)80007-1

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Histamine H2-receptor antagonists.

R Pounder

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Abstract

The first histamine H2-receptor antagonists were developed in the early 1970s, and they have a dominant role in today's management of peptic ulceration. The original regimens using either cimetidine or ranitidine attempted to control acidity across the 24 hours, but more 'modern' regimens use a large single dose of the H2-blocker in the evening, which produces a pulse of decreased intragastric acidity during the night with a normal acidity in the daytime. High-dose regimens using a new generation of extremely potent histamine H2-receptor antagonists may improve ulcer healing rates at 4 weeks, and may be particularly useful for the management of either severe oesophagitis or intractable duodenal ulceration.

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Animals Clinical Trials as Topic Duodenal Ulcer Esophagitis, Peptic Famotidine Histamine H2 Antagonists Humans Nizatidine Stomach Ulcer Thiazoles Clinical Trial Journal Article Review

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R Pounder. 1988. Histamine H2-receptor antagonists.. https://doi.org/10.1016/s0950-3528(88)80007-1

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