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PubMed · 2902710

Microsomal enzyme induction by permethrin in rats.

A Anadon·M J Diez·M Sierra·J A Sanchez·M T Teran
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Abstract

The synthetic pyrethroid, permethrin, was evaluated for its ability to alter hepatic microsomal drug-metabolizing function. The influence of permethrin (25:75 cis-trans) on plasma antipyrine kinetics and gamma-glutamyl transpeptidase (gamma-GTP) activity were studied in rats. After 3 days of administration of 90 mg permethrin/kg/day, there was no significant change in the antipyrine half-life and the area under the curve, while the apparent volume of distribution and clearance were significantly increased. Treatment with 190 mg permethrin/kg/day for 3 days decreased antipyrine half-life and the area under the curve, and increased the apparent volume of distribution and the clearance significantly. The gamma-GTP activity was significantly increased within 21 days and 14 days after the start of permethrin administration, at doses of 90 and 190 mg permethrin/kg/day, respectively. The antipyrine kinetics results indicate that permethrin is capable of producing a dose-dependent marked enzyme-inducing effect.

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AnimalsAntipyrineEnzyme InductionHalf-LifeInsecticidesMaleMicrosomes, LiverPermethrinPyrethrinsRatsRats, Inbred Strainsgamma-GlutamyltransferaseJournal ArticleResearch Support, Non-U.S. Gov't

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A Anadon, M J Diez, M Sierra, J A Sanchez, M T Teran. 1988. Microsomal enzyme induction by permethrin in rats.. https://pubmed.ncbi.nlm.nih.gov/2902710/

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