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Sodium cotransport systems in epithelial secretion.

R K Kinne
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Abstract

1. After considering the direct coupling and indirect coupling to the sodium gradient in sodium-dependent secretion across epithelia, the properties of the Na-K-Cl cotransporter involved in active chloride secretion and active chloride absorption are summarized. 2. A comparison between cellular mechanism of secretion and absorption shows that the direction of transepithelial transport is determined mainly by the intracellular localization of sodium cotransport systems and sodium-independent leaks. 3. Sodium cotransport systems, performing a similar function in various epithelia or species, may provide a powerful model to study their function at a molecular level.

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R K Kinne. 1988. Sodium cotransport systems in epithelial secretion.. https://doi.org/10.1016/0300-9629(88)90690-1

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