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PubMed · 2904344

Calcium and olfactory transduction.

B D Winegar·E R Rosick·R Schafer
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Abstract

1. Inorganic cations, organic calcium antagonists, and calmodulin antagonists were applied to olfactory epithelia of frogs (Rana pipiens) while recording electroolfactogram (EOG) responses. 2. Inorganic cations inhibited EOGs in a rank order, reflecting their calcium channel blocking potency: La3+ greater than Zn2+ greater than Cd2+ greater than Al3+ greater than Ca2+ greater than Sr2+ greater than Co2+ greater than Ba2+ greater than Mg2+. Barium ion significantly enhanced EOGs immediately following application. 3. Diltiazem and verapamil produced dose-dependent EOG inhibition. 4. Calmodulin antagonists inhibited EOGs without correlation to their anti-calmodulin potency.

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AnimalsCalciumCalcium Channel BlockersCalmodulinCationsElectrophysiologyOlfactory MucosaRana pipiensJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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B D Winegar, E R Rosick, R Schafer. 1988. Calcium and olfactory transduction.. https://doi.org/10.1016/0300-9629(88)90422-7

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