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Analytical problems encountered during high-performance liquid chromatographic separation and coulometric detection of bopindolol metabolites in human plasma.

S L Perkins·B Tattrie·P M Johnson·E Z Rabin
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Abstract

Good clinical control of hypertension is achieved with low doses of the potent beta-blocker bopindolol. Pharmacokinetic evaluations therefore require an analytical technique of high sensitivity. Analysis of plasma by high-performance liquid chromatography (HPLC) using electrochemical detection provides this sensitivity. This article describes the development of an analytical procedure and presents a reversed-phase HPLC method with coulometric detection suitable for plasma analyses during pharmacokinetic investigations of bopindolol therapy.

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Adrenergic beta-AntagonistsChromatography, High Pressure LiquidElectrochemistryHumansPindololReference StandardsSolventsJournal ArticleResearch Support, Non-U.S. Gov't

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S L Perkins, B Tattrie, P M Johnson, E Z Rabin. 1988. Analytical problems encountered during high-performance liquid chromatographic separation and coulometric detection of bopindolol metabolites in human plasma.. https://doi.org/10.1097/00007691-198804000-00019

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