PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 2920480

Antimicrobial therapy: past, present, and future.

A R Ronald
View original source ↗Export metadata ↓

Abstract

Antimicrobial chemotherapy is a growth industry in the rapidly changing world of health care. The identification of new pathogens, new treatment modalities, and new issues related to our patterns of antimicrobial use ensure that the practise of Infectious Diseases in 1994 will be markedly different than it has been in 1988. Ongoing adaptation and radical change will both be required of each one of us as we modify our treatment guidelines to ensure that our patients receive optimal antimicrobial therapy for maintaining or regaining their health.

Explore related subjects

4-QuinolonesAnti-Infective AgentsAntiviral AgentsCephalosporinsForecastingHumansPenicillinsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A R Ronald. 1989. Antimicrobial therapy: past, present, and future.. https://pubmed.ncbi.nlm.nih.gov/2920480/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

The 3-ethoxycarbonyl-4-quinolone compound 1 has previously been identified via a database search as an interesting lead compound for ligand binding at the benzodiazepine site of GABA(A) receptors (Kahnberg et al. J. Mol. Graphics Modelling 2004, 23, 253-261). Pharmacophore-guided optimization of this lead compound yielded a number of high-affinity ligands for the benzodiazepine site including compounds 20 and 23-25 displaying sub-nanomolar affinities. A few of the compounds have been tested on the alpha(1)beta(2)gamma(2S) and alpha(3)beta(2)gamma(2S) GABA(A) receptor subtypes, and two of the compounds (5 and 19) display selectivity for alpha(1)- versus alpha(3)-containing receptors by a factor of 22 and 27, respectively. This selectivity for alpha(1)beta(2)gamma(2S) is in the same range as that for the well-known alpha(1) subunit selective compound zolpidem.

4-Quinolones↗
PubMed2006

4-quinolone signalling in Pseudomonas aeruginosa: old molecules, new perspectives.

In Pseudomonas aeruginosa, diverse virulence determinants and secondary metabolites are regulated via the action of a hierarchical quorum-sensing system which integrates two chemically distinct classes of signal molecules, the N-acylhomoserine lactones (AHLs) and the 4-quinolones (4Qs). Synthesis of the pseudomonas quinolone signal, 2-heptyl-3-hydroxy-4-quinolone (PQS) depends on the pqsABCDE locus which is responsible for generating multiple 4Qs including 2-heptyl-4-quinolone (HHQ), the immediate PQS precursor. Exported HHQ is taken up by adjacent bacterial cells and converted into PQS by PqsH, a putative mono-oxygenase. In addition, PQS regulates its own production by driving the expression of pqsABCDE through a direct interaction with PqsR (MvfR). PQS regulates diverse target genes including those coding for elastase, rhamnolipid, the PA-IL lectin and pyocyanin via the action of PqsE as well as influencing biofilm development and impacting on cellular fitness. Furthermore, 4Q signalling is not restricted to P. aeruginosa raising the possibility of cross-talk with other related bacterial species which occupy similar ecological niches.

4-Quinolones↗