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PubMed · 2934551

Null cell immunoregulation in SLE.

H A Stephens·P Fitzharris·R A Knight·M L Snaith
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Abstract

Fresh normal T cells do not lyse MDA-157 target cells. Normal null cells, cultured for 4 days with MDA-157 stimulators, and then mixed overnight with fresh normal T cells, induce cytotoxicity on MDA-157 targets and suppressor activity in the T-cell acceptor population. With the same normal acceptor T cells, MDA-157 activated null cells from 13/18 patients with Systemic Lupus Erythematosus (SLE), unlike activated cells from a disease control population, induce little or no T-cell cytotoxicity or suppression. These results provide further evidence for abnormal null cell function in SLE.

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Cells, CulturedFemaleHumansImmune ToleranceLupus Erythematosus, SystemicLymphocyte ActivationLymphocyte Culture Test, MixedLymphocytes, NullT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryJournal ArticleResearch Support, Non-U.S. Gov't

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H A Stephens, P Fitzharris, R A Knight, M L Snaith. 1985. Null cell immunoregulation in SLE.. https://pubmed.ncbi.nlm.nih.gov/2934551/

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