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Mouse chromosome fragility.

M M Sanz·E C Jenkins·W T Brown·M T Davisson·M J Kevin·T H Roderick·W P Silverman·H M Wisniewski
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Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyuridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

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AnimalsCells, CulturedChromosome BandingChromosome Fragile SitesChromosome FragilityFloxuridineGenetic MarkersMiceMice, Inbred StrainsSpecies SpecificityComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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M M Sanz, E C Jenkins, W T Brown, M T Davisson, M J Kevin, T H Roderick, W P Silverman, H M Wisniewski. Mouse chromosome fragility.. https://doi.org/10.1002/ajmg.1320230141

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