Increased proliferative activity in selenium-deficient mouse liver.

R Otter; M Goldberg; S Vogl; A Wendel

doi:10.1016/s0009-2797(86)80074-6

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Increased proliferative activity in selenium-deficient mouse liver.

R Otter·M Goldberg·S Vogl·A Wendel

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Abstract

Male albino NMRI mice were fed a selenium-deficient (Se-), torula yeast-based diet containing less than 10 ppb Se for at least 2 months (Se-) while a control group received the same diet supplemented (Se+) with 330 ppb Se as Na2SeO3. The Se-(-)animals showed multiple enzyme modulations of liver enzyme activities indicating that they were in a severely Se- state. No significant difference in the basic DNA synthesis rate of Se-(-)animals compared to Se+ controls was measured. However, when liver cell proliferation was induced by either hepatopoietin pretreatment or by partial hepatectomy, an about 3-fold increase in DNA replication rates was found in Se- compared to controls. We conclude that the enhanced proliferative activity in Se- mouse liver is expressed in an emergency situation.

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Animals Blood Proteins DNA Hepatocyte Growth Factor Liver Male Mice Selenium Journal Article Research Support, Non-U.S. Gov't

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R Otter, M Goldberg, S Vogl, A Wendel. 1986-10-01. Increased proliferative activity in selenium-deficient mouse liver.. https://doi.org/10.1016/s0009-2797(86)80074-6

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